What is considered a very high level of alkaline phosphatase?

  • What is considered a very high level of alkaline phosphatase?

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    Q. What is considered a very high level of alkaline phosphatase?

    Alkaline phosphatase = ALP

    A. You have alkaline phosphatase throughout your body. If you show signs of liver disease or a bone disorder, your doctor may order an alkaline phosphatase (ALP) test to measure the amount of the enzyme in your blood and help in diagnosing the problem. Sometimes it’s part of a broader group of tests called a routine liver or hepatic panel, which checks how your liver is working.

    If your liver isn’t working right, the amount of ALP in your blood may be high. Doctors often use the test to look for blocked bile ducts. Other conditions that can cause problems with your liver include, but not limited to, cirrhosis of the liver. liver cancer, and bone disorders.

    The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you’re pregnant. The normal range for serum ALP level is 20 – 140 IU/L , but this can vary from laboratory to laboratory. The normal range runs higher in children and decreases with age.

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    It’s always necessary to use the reference ranges provided by the lab doing the tests. This is particularly important with alkaline phosphatase since there are two methods commonly in use and one of these has a reference range almost twice as high as the other. Contact the lab.

    Some common causes of elevated alkaline phosphatase (ALP) include:

    Liver disease (hepatitis, gallstones, cirrhosis, liver cancer…)

    Bone disease (Paget’s disease, bone cancer…)

    Obesity (why this happens is still unknown and is being researched)

    Tumors (Hodgkin’s lymphoma, lung cancer, ovarian cancer, prostate cancer, testicular cancer…)

    Pregnancy (not a cause for concern as this is normal in the third trimester, absent other health problems)

    Chronic kidney disease (also with diabetes, hypertension, and cardiovascular disease, which all affect the kidneys)

    Certain medications (birth control, steroids, other hormonal medications, anti-inflammatories, narcotics, antidepressants, anti-epileptics, anticonvulsants)

    To know the cause of YOUR elevated ALP, you need to speak to your physician.

    Generally high alk phos means permanent liver damage. Are you using medication legal or illegal? Tylenol is a big problem as is ibuprofen too. Alcohol is also a culprit. Not knowing your circumstances other prescription drugs may be at fault too. Knowing what it is is of course important. Stopping it can stop future damage. Not knowing what it is will keep it happening. Of course there are other things that can injure your liver. Seeing a gastroenterologist is certainly a good idea. Also keep your kidneys in good shape as they can stress the liver too.

    These are your blood stream’s serum level of liver enzymes the indicate it is NOT doing well. Jaundiced by NOW certainly.

    According to Google: “AST elevation generally indicates liver damage if ALT, bilirubin, and ALP are also elevated. – Very high AST levels (1000 units/L) are most commonly due to viral hepatitis, ischemic hepatitis or liver injury due to drug or toxin.

    Isolated AST elevation (without ALT elevation) may indicate cardiac or muscle disease”.

    Don’t worry about. Diagnostic use of enzymes depends on the death and lysis of cells in the tissues which contain them. Cells die and release their contents. The increased levels of enzymes correlate to specific tissues and indicate damage to that tissue. As tissue damage resolves the enzymes level go down to normal levels.

    Low AlkPhos is nothing to worry about.

    The ending -ase tells you it’s an enzyme (a biological catalyst that makes chemical reactions happen). A phosphatase is an enzyme that cleaves off phosphate groups. Alkaline just tells you what the best conditions are for the reaction – enzymes are (typically) proteins, and they have preferences for the pH at which they are active.

    The most famous alkaline phosphatase is the one used in molecular biology to remove the phosphate group at the 5′ ends of a linear piece of DNA. It’s a step used to make cloning (the cut and paste of DNA) more efficient. If you have a plasmid that you cut with a restriction endonuclease, it has phosphate groups at its ends. When you try to ligate (paste) a second piece of DNA with matching ends into the gap using ligase. the odds are that the plasmid just patches itself together again (Its own ends are just closer together than anything you add).

    To prevent that from happening, you cut off the 5′ end phosphates of the plasmid DNA. Now the ligase can’t work on it anymore. But if you add the piece of DNA you want to get in there, that piece still has 5′ phosphates, and the ligase can use that to connect it to the 3′ OH end of the plasmid. That still leaves you with a gap where the 5′ OH of the plasmid (you removed the phosphate that should be there) lines up with the 3′OH of the insert, but DNA repair will take care of that later on

    Well I went through this recently.

    I’m 19 and a few months ago I read somewhere that a human body needs at least 2 liters of water daily. So I got a water bottle of 1 litre and tried to finish it twice daily . But here’s the catch, though I was successful in drinking 2 liters of water for a few days but I didn’t feel good at all because I hardly did any physical work and thus I didn’t require that much amount of water. So I’d say that it depends on how much physical work you do. Try to drink at least 1–1.5 liters if u don’t do any physical work. That worked for me 🙂

    Ps- Try drinking 2 liters a day and see how it turns out. But I think you’ll just pee a lot :p

    Alkaline phosphatase is an enzyme produced by liver, bone, intestine, placenta, and some other organs and cells. It can be raised in a myriad conditions. In pregnancy and growing children, elevated levels are even normal.

    The result of a single lab test is like knowing one word- you do not even know whether it is a part of a sentence or a script. It gives you a clue, but unless you know the other words, and the context, it makes no sense.

    Example:

    Rains

    .

    Rains crops

    ..

    Rains crops flooded

    Rains crops flooded rescue

    .

    Timely rains saved the parched crops. The hearts of the farmers were flooded with joy as their crops were rescued.

    See how the context changes with each added word? It’s probably a hundred times more complex than that.

    So, to answer your question, it is impossible to interpret a single test without knowing the degree of elevation, your age, gender, multitude of clinical details, other relevant tests possibly involving liver, kidney, calcium metabolism etc.

    Please always consult your physician for specific queries. Lab results have to be interpreted with utmost caution.

    There are two sources

    liver and bone

    they can be differentiated in lab usual tests picks up both

    most common source in liver blockage of bile drainage like gallstones blocking also liver inflamations like different hepatitis

    bone normal in kids since they are growing also overactive parathyroids whether tumor or associated with kidney diseases

    an old and very useful lab test

    If you are male under 16, it may be normal. Alkaline phosphatase that is measured by normal lab investigation is derived from bone and bile ductular system in the liver and extra hepatic bile ducts. The two may be distinguished by performing isoenzyme levels. In any case you should run this by your primary care physician and perhaps a liver specialist if persistently elevated.

    Parathyroid gland secretes a hormone called parathhormone when the calcium level in blood goes below normal range so as to increase it to the normal range and keep a balance. This hormone does so by stimulating bone forming cells called osteoblasts to produce a protein called RANKL which in turn activates bone destroying cells called osteoclasts. These osteoclasts destroy bone and sends calcium from bone to blood. Once blood calcium attains normality, the Parathhormone will be inhibited by a negative feedback loop. All these happen in normal life physiology.

    Primary Hyperparathyroidism is a condition where there is a benign tumour(mostly called an adenoma) in the gland which keeps on secreting parathhormone despite the calcium being high (coz cancer cells doesn’t understand the negative feedback inhibition). So the bone keeps on getting weak as all the calcium is being removed by this excess hormone.

    On the other hand , parathhormone also stimulates formation of active vitamin D in the kidneys which in turn stimulates osteoblasts to secrete alkaline phosphatase (an enzyme required for bone formation) in order to deposit calcium and phosphorus in the already weakening bone by the tumour overactivity.

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